The Life-Extension Episode With Dr. Matt Kaeberlein | The Tim Ferriss Show

Rapamycin (sirolimus / Rapamune)

“that's the drug that i if i had to pick one intervention that's the one that i have focused on the most throughout my career”— Matt Kaeberlein

The Paleo Solution

Robb Wolf

“rob wolf who is a former research biochemist and two-time new york times best-selling author of the paleo solution and wired to eat”— Tim Ferriss

Wired to Eat

Robb Wolf

“two-time new york times best-selling author of the paleo solution and wired to eat rob created element by scratching his own itch”— Tim Ferriss

Acarbose

“there are other drugs like acarbose which is an anti-diabetic drug that is in males at least close to rapamycin in terms of the magnitude of effect”— Matt Kaeberlein

17-alpha estradiol

“17 alpha estradiol which is a sex hormone extends lifespan in males ndga is another one”— Matt Kaeberlein

NDGA (nordihydroguaiaretic acid)

“17 alpha estradiol which is a sex hormone extends lifespan in males ndga is another one”— Matt Kaeberlein

Metformin

“metformin which is the most commonly prescribed anti-diabetic drug in the world it's gotten a lot of attention for its potential effects on longevity”— Matt Kaeberlein

Nicotinamide riboside (NR)

“a nicotinamide riboside which is an nad precursor did not extend lifespan by the itp but there's a lot of evidence that you can have beneficial effects”— Matt Kaeberlein

Alpha-ketoglutarate

“one is alpha ketoglutarate which is a natural product metabolite that a lot of people are thinking about now there's one study that showed a small life span extension in mice”— Matt Kaeberlein

Spermidine

“two that actually are thought to target autophagy or mitophagy mitochondrial autophagy one is called spermadine and the other is called urolithin a”— Matt Kaeberlein

Urolithin A

“the other is called urolithin a and so i would take a close look at those”— Matt Kaeberlein

Deprenyl

“there's one that i have here in my notes that i'd love to know if you have any opinion on which is depranil”— Tim Ferriss

Smart Drugs

“freshman year reading volume one of a series well later became a series called smart drugs and it talked about off-label use of all sorts of things”— Tim Ferriss

Nicotinamide mononucleotide (NMN)

“there are two that are commonly talked about and studied nicotinamide riboside and nicotinamide mononucleotide”— Matt Kaeberlein

Modafinil

“almost all of the top sprinters in the world were diagnosed with narcolepsy because they wanted to use modafinil because it's a performance enhancer”— Tim Ferriss