Dr. Annette Bosworth (Dr. Boz): An internal medicine physician with 25 years of chronic-disease experience who specializes in insulin resistance and uses a medical-grade ketogenic diet with patients. She is a YouTube educator and author who once ran for US Senate.
What this episode covers
Dr. Boz explains how chronically elevated insulin, driven by processed food and late-night eating, silently builds 'trash' in the body and brain that fuels weight gain, brain fog, Alzheimer's, Parkinson's and cancer. She walks through how to get into ketosis, how to measure it with blood ketone and glucose readings (her 'Dr. Boz ratio'), and her 12-step keto continuum. The conversation covers patient case studies including her mother's cancer reversal and a Down syndrome patient's cognitive gains, plus tools like sardine fasts, exogenous ketones, creatine and methylene blue. It closes with her dramatic personal story of fighting Medicaid-fraud charges and 12 felonies tied to a US Senate run.
Recommended on this episode
Methylene Blue
various
“It was amazing. Like I I was floored at how well that little trick you worked... I put that in my morning morning coffee”— Annette Bosworth
The guest's own work
The Ketone Continuum: Consistently Keto for Life
Annette Bosworth (Dr. Boz)
“it's it's a book here I have which you published in 2020 called The Ketone Continuum Consistently Keto for Life”— Steven Bartlett
Anyway You Can: A Beginner's Guide to Ketones for Life
Annette Bosworth (Dr. Boz)
“this wonderful book called Anyway You Can, a Beginner's Guide to Ketones for Life, which um talks a lot about Rose”— Steven Bartlett
The Continuum Workbook
Annette Bosworth (Dr. Boz)
“we have the the Continuum Workbook, which is a much more practical um Yeah, it goes hand in hand with the other one”— Steven Bartlett
Also referenced (named, not recommended)
Alone
History
“Have you ever seen the the reality show Alone?... they drop these people off in the middle of nowhere and they starve them”— Annette Bosworth
Big reveals from this episode
- A 41-year-old Down syndrome patient with Alzheimer's spoke a three-syllable word for the first time after 3 weeks of keto.
- Dr. Boz admits she personally couldn't reach ketosis for ~9 months despite being a doctor, nearly dismissing keto as junk science.
- Live on-camera ketone tests: Steven's team and a guest (Jack) scored as low as 0.1 ketones, which she calls 'trash being made.'
- A patient (Jane) ate only sardines for 100 days, resolving emotional eating and tripling her vitamin D.
- Her mother's cancer numbers dropped 70% in 6 weeks on keto alone, versus the 30% expected from chemo.
- Dr. Boz was charged with 12 felonies and sentenced to 24 years in prison over unwitnessed campaign petitions.
- The South Dakota Supreme Court ruled the attorney general abused his power and all 12 felonies were erased.
Worth remembering
- She claims one bite of food after 6pm is worth ten bites before noon for aging metabolisms.
- Severely insulin-resistant patients can take up to 15 days on 20g carbs before producing a single ketone.
- Burning ketones is described as a cleaner, antioxidant fuel that crosses the blood-brain barrier without insulin's help.
- Soldiers on keto reportedly gained ~20% more power at 6 months and nearly 50% more by 18 months versus peers.
- A blue strip measures ketones and a brown strip measures glucose; she divides glucose by ketones for the 'Dr. Boz ratio.'
- She argues you need butyrate, not fiber, for a strong microbiome and dismisses fiber as 'for farting.'
- Methylene blue, once used as an anti-malarial, dyed soldiers' brains and hearts blue at autopsy, proving it reached the cells.
- Creatine supplementation can falsely elevate creatinine, making kidney blood tests look worse than reality.
- Exogenous ketones act as a signal telling the liver to make more ketones and to spare muscle mass over fat.
- Cancer cells often rely on glucose (the Warburg effect), the theoretical basis for keto 'starving' tumors.