The guest
Gary Brecka: Human biologist, longevity and human-optimization specialist, founder of 10x Health and host of The Ultimate Human podcast; known for helping Dana White transform his health.
What this episode covers
Gary Brecka tells Joe Rogan that the majority of modern pathology is really nutrient deficiency, centered on impaired methylation, and explains the five key genes (MTHFR, MTR, MTRR, AHCY, COMT) everyone should test once. He details how he reversed Dana White's life-threatening blood work using TMG for homocysteine, a prescription ketogenic diet, peptides, red light therapy, cold plunging and methylated supplements. Long tangents cover folic acid being a synthetic chemical sprayed on US grains, cyanocobalamin B12 as a cyanide-based form, fluoride and IQ, and seed oils being industrially processed lubricants. He champions free interventions first: sunlight, grounding, breath work and cold exposure. Joe shares his own fasted morning routine, kettlebell training and cold-plunge habit.
Recommended on this episode
ProductRecommended
TMG (Trimethylglycine)
“everybody with hypertension should consider”
“is this a amino acid that pretty much everybody should be taking it's an amino acid that everybody with hypertension should consider if they have high homosysteine”— Gary Brecka
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Methylfolate
“absolutely I encourage them”
“so do you encourage people to take methylfolate as a supplement or absolutely I encourage them I think everybody”— Gary Brecka
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SAM-e (S-adenosylmethionine)
“what would be a good supplement for them um Sam e”
“for someone who has a very hard time going to sleep at night like what would be a good supplement for them um Sam e magnesium”— Gary Brecka
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Thorne
Thorne
“Thorn is a great supplement”
“pure encapsulation is a great supplement th and Thorn is a great supplement I would rather people take the information”— Gary Brecka
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Pure Encapsulations
Pure Encapsulations
“pure encapsulation is a great supplement”
“pure encapsulation is a great supplement th and Thorn is a great supplement I would rather people take the information”— Gary Brecka
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BPC-157
“it's so effective ... it does so good for the gut”
“it's so effective I mean I can't even begin to tell you how many thousands and thousands of patients my clinical team has put on bpc 157 never with an adverse event it does so good for the gut”— Gary Brecka
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LMNT (Element)
LMNT
“I like that stuff”
“prior to that I was using eln um yeah I like that stuff yeah I like that stuff too I used liquid IV too”— Joe Rogan
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Celtic Sea Salt
“probably the best salt you can put in the body by far”
“the Celtic Sea salt which is inexpensive is probably the best salt you can put in the body by by far”— Gary Brecka
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Mountain Valley Spring Water
“if you're going to drink spring water drink Mountain Valley”
“if you're going to drink spring water drink um um Mountain Valley but if you um by the way I don't have any deal with mountain valy”— Gary Brecka
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Echo hydrogen water system
Echo
“the one that I use”
“I link to the one that I use on my Instagram foret the name of it but um I think it's the echo echo water filtration”— Gary Brecka
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Piceid Resveratrol
Vine Virtual
“the one that I take ... it is astounding the clinical outcomes”
“where would someone get that um I got got a link to the one that I take on my Instagram I get it from Vine virtual”— Gary Brecka
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NMN
“I'm a huge fan of nmn”
“I'm a huge fan of nmn I'm a massive fan of R veratrol um you know stem cell stimulatory supplements”— Gary Brecka
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Resveratrol
“I'm a massive fan of R veratrol”
“I'm a huge fan of nmn I'm a massive fan of R veratrol um you know stem cell stimulatory supplements”— Gary Brecka
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Micellized turmeric and curcumin drops
10x Health
“immediately knock down inflammation ... that problem just eviscerates”
“I also put him on a mized turmeric and corcumin drops so these are nanoparticle turmeric and corcumin with bio Alo that you put under the tongue”— Gary Brecka
The guest's own work
ProductBy the guest
10x Health genetic methylation test
10x Health
“that's why I say I think everybody at once in their lifetime should do a genetic methylation test”— Gary Brecka
ProductBy the guest
10x Optimize multivitamin
10x Health
“then I put him on a 10x multivitamin it's called optimize it's actually a vitamin I designed myself it took me about two and a half years”— Gary Brecka
ProductBy the guest
10x Brain and Immune Boost
10x Health
“I went aggressively after the inflammation um with one of the products I make myself which is called 10x brain and immune boost”— Gary Brecka
ProductBy the guest
10x Health red light bed
10x Health
“we partnered with da Vinci medical and thly 360 to make one of the most powerful red light beds on the market what's it called um it's called the 10x”— Gary Brecka
Also referenced (named, not recommended)
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Theralight 360
Theralight
“we partnered with da Vinci medical and thly 360 to make one of the most powerful red light beds on the market”— Gary Brecka
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Joovv
Joovv
“but the ju they don't make one that juices you up the way yours does no God no no that's 125 Ms of Radiance more powerful”— Gary Brecka
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Sermorelin
“we also put them on a peptide um at the time it was a growth hormone peptide sorin and ipom Morin”— Gary Brecka
ProductReferenced
Ipamorelin
“we also put them on a peptide um at the time it was a growth hormone peptide sorin and ipom Morin”— Gary Brecka
ProductReferenced
CJC-1295
“I Morin cgc 1295 mk677 ibutamoren these growth hormone peptides that kept people off of exogenous growth hormone”— Gary Brecka
ProductReferenced
MK-677 (ibutamoren)
“I Morin cgc 1295 mk677 ibutamoren these growth hormone peptides that kept people off of exogenous growth hormone”— Gary Brecka
ProductReferenced
Creatine
“you can do all of those additional things ... you can take um you know creatine to help with with muscles”— Gary Brecka
ProductReferenced
HyperMax multi-step oxygen therapy
“he does use something called hypermax multi-step oxygen therapy again all of which you can do for no cost”— Gary Brecka
ProductReferenced
Morozko Forge cold plunge
Morozko Forge
“I have two different ones I have the morasco at home which gets down to 33 and then I have the one here that's a little higher”— Joe Rogan
ProductReferenced
Blue Cube cold plunge
Blue Cube
“that's the blue cube you don't get any thermal layer at all you just suck it the entire time you just can't hide”— Joe Rogan
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Alpha Brain pre-workout
Onnit
“I do take uh Alpha Brain preworkout which is got beta alanine B12 some caffeine it's woo that stuff got a lot of”— Joe Rogan
ProductReferenced
5-HTP
“like with 5 HTP with like turning methylation back on with five methyl folate with the complex of B vitamins”— Gary Brecka
Big reveals from this episode
- Brecka fixed Dana White's 15-year 'hypertension' with cheap over-the-counter TMG (trimethylglycine), not heart drugs, after finding sky-high homocysteine.
- Folic acid is an entirely man-made synthetic chemical sprayed on US grains since ~1993, and 40-60% of people can't convert it to usable methylfolate.
- He says the FDA cracked down on the peptide BPC-157 for lack of paid safety data, not for any actual safety problem.
- Brecka claims specific red-light wavelengths force oxygen to dock in the mitochondria for up to a 16-fold increase in cellular energy.
- After ~10-12 weeks Dana White lost ~48 lbs, normalized blood pressure, came off all cardiovascular meds, and homocysteine fell from the 30s to single digits.
- He argues most 'hypothyroid' diagnoses are actually a gut/methylation problem converting T4 to T3, not a failing thyroid.
- He tells listeners to permanently stop drinking tap water, citing fluoride as a neurotoxin inversely correlated with IQ.
Worth remembering
- High homocysteine is one of the most inflammatory compounds in the body and narrows arteries, driving blood pressure up with nothing wrong with the heart.
- Chronic vitamin D3 deficiency is often misdiagnosed as rheumatoid arthritis; resulting corticosteroids can lead to a joint replacement within six years.
- Cyanocobalamin, the most common B12 form, is cyanide-based and must be converted by the body; it's found in Flintstones and many vitamins.
- Brecka cites an inverse relationship between fluoride concentration and IQ across 3,600 US municipalities.
- Toothpaste labels warn to call Poison Control if swallowed, yet fluoride is added to drinking water.
- Water pulls heat from the body 29 times faster than air, which is why you can die in 72-degree water but not 72-degree air.
- Grass-fed animal fats produce 'deuterium-depleted' light water inside cells that doesn't break the Krebs cycle.
- He claims hydrogen water has roughly 1,400 published peer-reviewed studies, more than any other water type.
- Joe details his fasted morning routine: cold plunge, then 100 push-ups and squats, plus kettlebell training based on Pavel Tsatsouline's StrongFirst method.
- Diets high in dietary folate (leafy greens, grass-fed meats, eggs, dairy) correlate with lower incidences of cancer.
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