Dr. Pradeep Jamnadas: A world-leading cardiologist with about 35 years of practice who has treated upwards of a quarter-million patients with chronic heart disease. He now does public education on preventing heart disease through diet, fasting and lifestyle, with a YouTube channel nearing a million subscribers.
What this episode covers
Dr. Jamnadas argues that coronary artery disease, the world's leading cause of death, is fundamentally a disease of inflammation driven by chronically high insulin, visceral fat, processed foods and frequent eating. He explains the glucose-insulin cycle, how insulin resistance forms years before a diabetes diagnosis, and why fasting (not mere calorie restriction) uniquely lowers insulin and burns dangerous visceral fat first. The conversation ranges across the gut microbiome and leaky gut, environmental toxins including mold, calcium versus vitamins D3/K2, the dangers of small dense oxidized LDL, and the vagus nerve's role in heart rhythm. He closes with concrete screening advice (coronary calcium score plus an inflammation panel) and a personal reflection on losing his father.
Recommended on this episode
Inulin with FOS
“because our diets today don't give us enough fiber, I do advise all my patients to take inulin with FOS”— Dr. Pradeep Jamnadas
Nattokinase
“My fibrinogen level was at the upper limits of normal, so I just take nattokinase. It doesn't cause any bleeding”— Dr. Pradeep Jamnadas
MegaSporeBiotic
Microbiome Labs
“And then I also take a probiotic. And I it's it's basically is called Mega Spores probiotic. So, this is spores”— Dr. Pradeep Jamnadas
Also referenced (named, not recommended)
LMNT
LMNT
“there's an electrolyte called Element T or sometimes I just tell them to go buy some Celtic salt and put half a teaspoon in there”— Dr. Pradeep Jamnadas
MCT oil
“If you get cravings and you feel really really hungry, take some MCT oil, a teaspoon, and put it in your water”— Dr. Pradeep Jamnadas
Peloton
Peloton
“the next day I cycled just over 100 km on my Peloton at home. Funnily enough, it took me like 4 hours to do it”— Steven Bartlett
Big reveals from this episode
- Claims white rice now contains so much arsenic that he has to coach patients on how to soak and cook it.
- His youngest heart-attack patient was 28, overweight with visceral fat and a fatty liver but only prediabetic, not diabetic.
- Says he fasted one severely overweight, diabetic woman for 72 days under supervision, reversing her diabetes and blood pressure.
- Reports a patient who fasted 183 days under supervision, dropping from 400 lb to 210 lb.
- Contrarian claim: people who over-do aerobic exercise end up with MORE coronary disease than those doing sprints and resistance work.
- Says almost 70% of homes have some mold toxicity, and clearing mold flattens the progression of coronary artery disease.
- States the most recent data shows people with the highest LDL can live healthier into their 90s; it's damaged LDL, not LDL itself, that's the problem.
- Reveals his most difficult day was his father's death, and that he second-guessed himself even as a cardiologist.
Worth remembering
- In the first 12 hours of a fast the body burns glycogen; only after 12 hours does it start pulling out fat, and visceral fat goes first.
- Ketones are a 'cleaner' fuel that produce fewer reactive oxygen species and boost brain-derived neurotrophic factor.
- He says you should have essentially zero coronary calcium in your artery walls.
- Calcium supplements can raise cardiovascular risk; the real fix is vitamin D3 and K2, not extra calcium.
- You're meant to eat 30 to 40 different types of vegetables a week to feed a diverse gut microbiome.
- One night of bad sleep can make you insulin resistant the very next day.
- Cooking rice then cooling it overnight creates 'resistant starch,' blunting its insulin and weight-gain effect.
- Burning or over-frying food creates advanced glycation end products that drive inflammation.
- Coffee's real benefit isn't caffeine but its soluble fiber and polyphenols that feed gut bacteria.
- A simple vagus-nerve hack: breathe in for a count of four, out for a count of eight, about ten minutes a day.